Dorothee Dormann Selected Research

Karyopherins (Importin)

12/2020	Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
4/2016	Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
11/2012	Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
9/2011	FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
8/2010	ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

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Dorothee Dormann Research Topics

Disease

14	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2024 - 08/2009
14	Sarcoma (Soft Tissue Sarcoma) 11/2022 - 08/2010
13	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2023 - 08/2009
10	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2024 - 07/2011
5	Frontotemporal Dementia (Semantic Dementia) 01/2022 - 08/2009
2	Proteostasis Deficiencies 09/2013 - 09/2011
1	Muscular Diseases (Myopathy) 12/2023
1	TDP-43 Proteinopathies 11/2023
1	Gliosis 11/2023
1	Body Weight (Weight, Body) 11/2023
1	Stab Wounds (Stab Wound) 12/2022
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Ewing Sarcoma (Sarcoma, Ewing) 09/2011
1	Pathologic Processes 09/2011
1	Infections 10/2009

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 12/2023 - 10/2009
9	DNA-Binding Proteins (DNA Binding Protein)IBA 05/2024 - 02/2011
6	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2023 - 09/2011
5	Karyopherins (Importin)IBA 12/2020 - 08/2010
4	Protein AggregatesIBA 12/2020 - 09/2013
4	DNA (Deoxyribonucleic Acid)IBA 04/2016 - 08/2009
2	RNA (Ribonucleic Acid)IBA 11/2022 - 01/2019
2	RNA-Binding Protein FUSIBA 11/2022 - 07/2011
2	Nuclear RNAIBA 01/2021 - 01/2018
2	Carrier Proteins (Binding Protein)IBA 01/2021 - 01/2018
2	Arginine (L-Arginine)FDA Link 12/2020 - 11/2012
2	messenger ribonucleoproteinIBA 01/2017 - 01/2016
2	Messenger RNA (mRNA)IBA 01/2016 - 09/2013
2	UbiquitinIBA 07/2011 - 02/2011
2	ProgranulinsIBA 02/2011 - 08/2009
1	PrionsIBA 12/2023
1	Peptides (Polypeptides)IBA 11/2023
1	microtubule-associated protein 1B (MAP5)IBA 11/2022
1	Serine (L-Serine)FDA Link 01/2022
1	Hormones (Hormone)IBA 01/2022
1	DipeptidesIBA 12/2020
1	Lysine (L-Lysine)FDA Link 01/2019
1	Amyloid (Amyloid Fibrils)IBA 01/2019
1	tau Proteins (tau Protein)IBA 01/2019
1	poly(glycyl-alanyl)IBA 02/2017
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 04/2016
1	Nuclear Localization Signals (Nuclear Localization Signal)IBA 11/2012
1	Nuclear Proteins (Protein, Nuclear)IBA 11/2012
1	Proline (L-Proline)FDA Link 11/2012
1	Tyrosine (L-Tyrosine)FDA Link 11/2012
1	Poly(A)-Binding Proteins (Poly(A)-Binding Protein)IBA 06/2012
1	TATA-Box Binding Protein (TATA-Binding Protein)IBA 09/2011
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 02/2011
1	Indicators and Reagents (Reagents)IBA 02/2011
1	Viral ProteinsIBA 10/2009
1	CaspasesIBA 08/2009

Therapy/Procedure

1	Therapeutics 11/2023